The spontaneous regression of a sequestrated cervical disc with root pain is regarded as a rare entity. The literature about this issue is limited to isolated case reports or small series of 2 to 6 cases. The authors have conducted a prospective study of 26 patients with acute upper extremity monoradiculopathy that was confirmed to be caused by a sequestrated cervical disc that migrated and lodged in the vicinity of one foramen. This phenomenon of regression occurred in all 26 subjects with clinical improvement. The marked resorption of the fragmented disc was observed simultaneously during a control MRI done within three to four months after the initial MRI for all of the subjects. Therefore, the simple conclusion was reached that we should not underestimate the possibility of regression in the evaluation and management of patients with an extruded- migrated cervical disc. In this study, the clinical picture and predictive imaging features will be described as guidelines for postponing surgery and waiting for resorption in subjects with acute cervical disc herniation. Furthermore, we will clarify the corresponding morphological changes as well as possible biomechanical and biological mechanisms of this phenomenon over time.